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Cross Study Team Retreat, 2012

Originally funded by the National Institute on Drug Abuse in 2004, the Cross Study Project began with the aim of identifying markers, mediators and moderators of risk for an early-emerging internalizing pathway of risk for substance use and disorder within the first four decades of life.  The theoretical foundations of this work appear in Hussong, Jones, Stein, Baucom & Boeding (2011) and delineate markers of progression along this risk pathway. Through the pursuit of derivable hypotheses from this model, this team developed Integrative Data Analysis (IDA), a novel approach to simultaneously analyzing primary data from multiple, independent studies through pooled analyses (for more details see Hussong, Curran & Bauer, 2013).


Our early work benefited from the nationally recognized studies conducted by Robert Zucker at the University of Michigan (The Michigan Longitudinal Study), Laurie Chassin at Arizona State University (The Adolescent/Young Adult Family and Development Project), and Ken Sher at the University of Missouri-Columbia (The Alcohol Health Behavior Project).  References below report key findings from the Cross Study Project over the years.

Currently, our group is conducting a series of computer simulation and experimental studies to determine optimal approaches to scoring and harmonizing measures that may differ in various ways across studies. Dan Bauer is the PI on this current grant along with Andrea Hussong and Patrick Curran. This is the core challenge of Integrative Data Analysis and this NIDA-funded project will allow us to make clear recommendations to field.



Burns, A.R., Hussong, A.M., Solis, J.M., Curran, P.J., McGinley, J.S., Bauer, D.J., Chassin, L., & Zucker, R.A. (in press). Examining Cohort Effects in Developmental Trajectories of Substance Use. International Journal of Behavioral Development.

Curran, P.J., Cole, V., Bauer, D.J., Hussong, A.M., & Gottfredson, N. (2016). Improving factor score estimation through the use of observed background characteristics. Structural Equation Modeling, 23, 827-844.

Curran, P. J., McGinley, J. S., Bauer, D. J., Hussong, A. M., Burns, A., Chassin, L. Sher, K., & Zucker, R. (2014). A moderated nonlinear factor model for the development of commensurate measures in Integrative Data Analysis. Multivariate Behavioral Research, 49(3), 214-231. doi: 10.1080/00273171.2014.889594. PMCID: PMC4423418.

Bauer, D. J., Howard, A. L., Badasaro, R. E., Curran, P. J., Hussong, A. M., Chassin, L., Zucker, R. A. (2013). A tri-factor model for integrating ratings across multiple informants. Psychological Methods, 18(4), 475-493. doi:1037/a0032475. PMCID: PMC3964937.

Hussong, A. , Curran, P. J. & Bauer, D. J. (2013). Integrative data analysis in clinical psychology research, Annual Review of Clinical Psychology, 9, 61-89. doi: 10.1146/annurev-clinpsy-050212-185522. PMCID: PMC3924786.

Hussong, A. , Huang, W., Serrano, D., Curran, P. J., & Chassin, L. (2012). Testing whether and when parent alcoholism uniquely affects various forms of adolescent substance use. Journal of Abnormal Child Psychology, 40(8), 1265-1276. doi: 10.1007/s10802-012-9662-3. PMCID: PMC3473117.

Curran, P.J. & Hussong, A.M. (2011). Integrative data analysis:  The simultaneous analysis of multiple data sets.  Psychological Methods, Special  Issue: Multi-Study Methods for Building a Cumulative Psychological Science, 14, 81-100.  PMCID: PMC2777640

Bauer, D.J., & Hussong, A.M. (2009). Psychometric approaches for developing commensurate measures across independent studies: traditional and new models.  Psychological Methods, Special  Issue: Multi-Study Methods for Building a Cumulative Psychological Science, 14, 101-125. PMCID: PMC2780030

Hussong, A.M., Flora, D.B., Curran, P.J., Chassin, L.A., & Zucker, R.A,. (2008). Defining risk heterogeneity for internalizing symptoms among children of alcoholic parents: A prospective cross-study analysis.  Development and Psychopathology, 20, 165-193. PMCID: PMC2249558

Hussong, A.M., Wirth, R.J., Edwards, M.C., Curran, P.J., Chassin, L.A. & Zucker, R.A. (2007). Externalizing symptoms among children of alcoholic parents: Entry points for an antisocial pathway to alcoholism.  Journal of Abnormal Psychology, 116, 529-542. PMCID: PMC2842994

Curran, P.M., Hussong, A.M., Cai, L., Huang, W., Chassin, L., Sher, K.J., & Zucker, R.A. (2008). Pooling data from multiple prospective studies: The role of item response theory in integrative analysis. Developmental Psychology, 44, 365-380.